Circulating miR-12136 is Associated with Symptom Severity in Patients with Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction
Atrial fibrillation (AF) frequently coexists with heart failure with preserved ejection fraction (HFpEF), a subgroup characterized by poor prognosis resulting in increased morbidity and mortality. Although circulating microRNAs (miRNAs) have emerged as promising biomarkers reflecting cardiovascular pathophysiology, miRNA signatures associated with disease severity in AF-HFpEF remain poorly characterized. This study aimed to identify circulating miRNAs associated with disease severity in patients with AF-HFpEF and to investigate their potential biological functions.