Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps  Associated with Allergic Sensitization
Juvenile colorectal polyps (JP) are the most common polypoid lesions of the colon in childrenand the leading cause of lower gastrointestinal bleeding in pediatric patients. Althoughhistologically classified as benign hamartomatous lesions, they arise in a context of allergicsensitization and IgE-mediated inflammation, suggesting that the epithelial compartment mayplay an active role in their pathogenesis. To date, most studies have focused on the immune cellinfiltrate, leaving the molecular programs operating within the epithelium largely unexplored.