Single-Cell Multi Omics Analysis Reveals Cellular Subpopulations Associated with Relapse in High-Risk B-ALL Following Intensified Chemotherapy
Using scRNA-seq and scATAC-seq on PBMCs from high-risk B-ALL patients post early intensified chemotherapy, this study identifies distinct drug-resistant HSC/MPP and Pro-B subclusters linked to treatment failure, illuminating B-ALL resistance mechanisms and aiding targeted therapies.