Impact of dietary sanguinarine on gut microbiota and immune function in growing lambs
This study examines the effects of dietary sanguinarine (SNG) on gut microbiota and immunity in growing lambs. Twenty-four lambs were assigned to four groups: control, low-dose SNG (200 mg/kg BW), high-dose SNG (800 mg/kg BW), or diclazuril positive control. After 28 days, fecal samples from four replicates per group underwent 16S rRNA V3-V4 sequencing. Data will reveal microbial shifts, key responsive taxa (e.g., Blautia), and support integrative analysis with metabolomics and immune markers to explore the microbiota-metabolite-immune axis. This project offers mechanistic insights into plant alkaloid modulation of ruminant health.