RNA-seq of RSC96 rat Schwann cells treated with PPB hydrogel extract under oxidative stress
To investigate the transcriptional response of Schwann cells to PPB under oxidative stress, RSC96 cells were exposed to 50 uM H2O2 for 1 h and then cultured for 24 h in either normal medium (CON) or PPB hydrogel extract (PPB). PPB is a baicalin-stabilized polyphosphate hydrogel formed from HACC, PolyP, and baicalin. Bulk RNA sequencing was performed on three replicate libraries per condition using an Illumina HiSeq X Ten platform. This dataset supports analysis of PPB-associated changes in gene expression programs related to cell proliferation, DNA replication and repair, energy metabolism, inflammatory signaling, and the PI3K/AKT/mTOR pathway.