GeoMX spatial transcriptomics of diffuse pleural mesothelioma: impact of CDKN2A deletion
We compared GeoMX spatially resolved gene expression profiles of diffuse pleural mesothelioma (DPM) samples with or without somatic CDKN2A deletion.  5 CDKN2Adel and 4 WT DPM samples were analyzed. A total of 202 Areas Of Illumination (AOIs) were transcriptionally profiled, of which 140 Sarcomatoid-AOIs (S-AOIs) and 62 Epithelioid-AOIs (E-AOIs). Collectively, 97 AOIs belonged to WT DPM and 105 to CDKN2Adel DPMs.Profiling was performed using the GeoMx™Digital Spatial Profiler with Cancer Transcriptome Atlas panel.
We compared GeoMX spatially resolved gene expression profiles of diffuse pleural mesothelioma (DPM) samples with or without somatic CDKN2A deletion.  5 CDKN2Adel and 4 WT DPM samples were analyzed. A total of 202 Areas Of Illumination (AOIs) were transcriptionally profiled, of which 140 Sarcomatoid-AOIs (S-AOIs) and 62 Epithelioid-AOIs (E-AOIs). Collectively, 97 AOIs belonged to WT DPM and 105 to CDKN2Adel DPMs.Profiling was performed using the GeoMx™Digital Spatial Profiler with Cancer Transcriptome Atlas panel.
European Bioinformatics Institute