RNA-seq of Human Prostate Cancer cell lines (LNCaP and 22RW1) with T2ERG expression
Gene fusions between the ETS family transcription factor ERG and the regulatory region of an androgen receptor (AR)-regulated gene (mainly TMPRSS2) characterize about 50% of prostate cancers (PCa) and represent early somatic events that co-initiate tumorigenesis. Yet, the molecular programs unleashed by ERG at disease onset remain elusive. Here, we used an inducible, temporally controlled system to express ERG in prostate cells (LNCaP and 22Rv1) for the accurate mapping of early ERG-driven processes.
Gene fusions between the ETS family transcription factor ERG and the regulatory region of an androgen receptor (AR)-regulated gene (mainly TMPRSS2) characterize about 50% of prostate cancers (PCa) and represent early somatic events that co-initiate tumorigenesis. Yet, the molecular programs unleashed by ERG at disease onset remain elusive. Here, we used an inducible, temporally controlled system to express ERG in prostate cells (LNCaP and 22Rv1) for the accurate mapping of early ERG-driven processes.
European Bioinformatics Institute