ATAC-seq analysis of LPS-trained bone marrow derived macrophages (BMDMs) from WT and SLC1A5_var transgenic mice.
The aim of this study is to evaluate the changes in the chromatin accessibility landscape of BMDMs from WT and SLC1A5_var transgenic mice after low-dose LPS training. We compared the data of ATAC-seq performed on nuclei extracted from naive and trained BMDM from both genotypes. Inter-group comparisons revealed differentially accessible regions to occur between traind WT and Tg BMDMs. Since SLC1A5_var function as unique mitochondrial glutamine transporter, the results indicate that altered glutaminolysis could impact chromatin accessbility.
The aim of this study is to evaluate the changes in the chromatin accessibility landscape of BMDMs from WT and SLC1A5_var transgenic mice after low-dose LPS training. We compared the data of ATAC-seq performed on nuclei extracted from naive and trained BMDM from both genotypes. Inter-group comparisons revealed differentially accessible regions to occur between traind WT and Tg BMDMs. Since SLC1A5_var function as unique mitochondrial glutamine transporter, the results indicate that altered glutaminolysis could impact chromatin accessbility.
European Bioinformatics Institute