Establishment of alcohol-tolerant gut microbiota in Koreans by frequent alcohol consumption
Alcoholic beverage is one of the most consumed foods worldwide. The purpose of this study was to investigate the effect of the amount of alcohol consumed on the structure of the human gut microbiota. The results indicated that the major source before drinking alcohol increased in the alcohol frequency group. The relative abundance of Agathobacter, Butyricoccus, Monoglobus, Eubacterium ventriosum group, and Bifidobacterium decreased when alcohol was consumed in the group with high alcohol frequency. In contrast, the genus of Lawsonella, Escherichia, Flavonifactor, and Subdoligranulum was increased by alcohol consumption in the alcohol infrequency group. The relative abundance of Anaerostipes, Lachnospira, and Lachnospiraceae CAG-56 increased both before and after drink in the alcohol frequency group. Based on KEGG pathways, predictive functions were also divided according to alcohol frequencies. Epithelial cell signaling in Helicobacter pylori infection metabolism increased in the frequency group, while linoleic acid metabolism was expressed in the alcohol infrequency group. These results suggest that the frequency of consumption of alcoholic beverages causes differences in the structure of the gut microbiota, which requires a study of alcohol-tolerant bacteria.
Alcoholic beverage is one of the most consumed foods worldwide. The purpose of this study was to investigate the effect of the amount of alcohol consumed on the structure of the human gut microbiota. The results indicated that the major source before drinking alcohol increased in the alcohol frequency group. The relative abundance of Agathobacter, Butyricoccus, Monoglobus, Eubacterium ventriosum group, and Bifidobacterium decreased when alcohol was consumed in the group with high alcohol frequency. In contrast, the genus of Lawsonella, Escherichia, Flavonifactor, and Subdoligranulum was increased by alcohol consumption in the alcohol infrequency group. The relative abundance of Anaerostipes, Lachnospira, and Lachnospiraceae CAG-56 increased both before and after drink in the alcohol frequency group. Based on KEGG pathways, predictive functions were also divided according to alcohol frequencies. Epithelial cell signaling in Helicobacter pylori infection metabolism increased in the frequency group, while linoleic acid metabolism was expressed in the alcohol infrequency group. These results suggest that the frequency of consumption of alcoholic beverages causes differences in the structure of the gut microbiota, which requires a study of alcohol-tolerant bacteria.
University of California San Diego Microbiome Initiative