Exon sequencing of mouse tails and respective tumors from mice with VBPN genetic background
BRAF mutant colorectal cancer displays a unmet clinical need with poor overall survival. Here we modeled this cancer in the murine system with Braf activation mutation, Trp53 deletion and Nicd1 expression. The respective alleles are recombined in the intestinal epithelium upon systemic tamoxifen injection. Tumors were occuring in the small intestine and in the colon. We conducted exon sequencing to investigate if other mutations occur in the tumor development.
BRAF mutant colorectal cancer displays a unmet clinical need with poor overall survival. Here we modeled this cancer in the murine system with Braf activation mutation, Trp53 deletion and Nicd1 expression. The respective alleles are recombined in the intestinal epithelium upon systemic tamoxifen injection. Tumors were occuring in the small intestine and in the colon. We conducted exon sequencing to investigate if other mutations occur in the tumor development.
European Bioinformatics Institute