RNAseq of KRT14+ progenitor cells from macrophage-proficient versus macrophage deficient mouse submandibular salivary gland
The salivary glands often become damaged in individuals receiving radiotherapy for head and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their health and quality of life, for which there is no regenerative therapy. Progenitor cells can replenish damaged tissue. We have shown the macrophages interact with KRT14+ basal epithelial progenitor cells; however, their function is unknown. Here, using bulk RNAseq we profile the transcriptomes of KRT14+ cells isolated from adult mouse submandibular salivary gland 14 days after targeted irradiation which is either macrophage-proficient or macrophage-deficient. For each sample equal numbers of cells from 8 mice were pooled.
The salivary glands often become damaged in individuals receiving radiotherapy for head and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their health and quality of life, for which there is no regenerative therapy. Progenitor cells can replenish damaged tissue. We have shown the macrophages interact with KRT14+ basal epithelial progenitor cells; however, their function is unknown. Here, using bulk RNAseq we profile the transcriptomes of KRT14+ cells isolated from adult mouse submandibular salivary gland 14 days after targeted irradiation which is either macrophage-proficient or macrophage-deficient. For each sample equal numbers of cells from 8 mice were pooled.
European Bioinformatics Institute