DNA methylome and transcriptomic hepatic responses of juvenile Xenopus tropicalis exposed to the fungicide imazalil
The extensive use agricultural pesticides have caused widespread environmental contamination, raising concerns about their adverse effects on wildlife and human health. The fungicide imazalil is used in post-harvest treatment of fruits, often leaving residues in citrus products, and contaminating soil and water in areas where it is heavily used. Imazalil is known to cause endocrine-disrupting effects in vertebrates, but its epigenetic mechanisms remain understudied. In this multi-omics study, we investigate the DNA methylation and transcriptomic effects of imazalil on the liver of Xenopus tropicalis juveniles (aged 6.5 weeks post-metamorphosis) after exposure to an environmentally relevant concentration of imazalil (12.3 µg/L) for 2 weeks.
The extensive use agricultural pesticides have caused widespread environmental contamination, raising concerns about their adverse effects on wildlife and human health. The fungicide imazalil is used in post-harvest treatment of fruits, often leaving residues in citrus products, and contaminating soil and water in areas where it is heavily used. Imazalil is known to cause endocrine-disrupting effects in vertebrates, but its epigenetic mechanisms remain understudied. In this multi-omics study, we investigate the DNA methylation and transcriptomic effects of imazalil on the liver of Xenopus tropicalis juveniles (aged 6.5 weeks post-metamorphosis) after exposure to an environmentally relevant concentration of imazalil (12.3 µg/L) for 2 weeks.
karlsson laboratory