Chromatin_Interaction_Mouse_Brain_Chen_Core
Elucidating the landscape of long-distance chromatin interactions within the developing mouse brain
We aim to elucidate the landscape of long-distance chromatin interactions within the developing mouse brain to gain deeper insights into the dynamic regulatory processes governing neurodevelopment. By employing barcoded dendron - a novel chromatin conformation capture techniques, we will investigate how spatial genome organisation influences neuronal differentiation, migration, and maturation. This study will provide a comprehensive view of chromatin architecture changes during key stages of brain development, shedding light on the epigenetic mechanisms that contribute to neurogenesis.
Wellcome Sanger Institute