Recombinant Fab Fragment Derived from a Monoclonal Antibody Targeting a Bacterial Surface Glycan
This study describes the sequence of a recombinant Fab fragment derived from a monoclonal antibody isolated during a project investigating human antibody responses to bacterial surface glycans. The Fab was cloned and expressed in a recombinant system, and its amino-acid sequence was determined to support structural and functional characterization. The deposited sequence represents the engineered light- and heavy-chain variable regions assembled as a Fab construct. The sequence is provided to enable reproducibility, facilitate comparative analyses of glycan-binding antibodies, and support future computational and structural studies.
This study describes the sequence of a recombinant Fab fragment derived from a monoclonal antibody isolated during a project investigating human antibody responses to bacterial surface glycans. The Fab was cloned and expressed in a recombinant system, and its amino-acid sequence was determined to support structural and functional characterization. The deposited sequence represents the engineered light- and heavy-chain variable regions assembled as a Fab construct. The sequence is provided to enable reproducibility, facilitate comparative analyses of glycan-binding antibodies, and support future computational and structural studies.
Federal Institute of Technology Zuerich