Primary ciliary dyskinesia in Cocker spaniels in Australia
Primary ciliary dyskinesia (PCD) is a clinical syndrome that in dogs primarily manifests as chronic respiratory disease associated with cilial malfunction. The current study employs whole genome sequencing and a candidate gene approach to uncover the genetic basis of PCD in three Cocker spaniel siblings following diagnosis of their respiratory cilia by scanning electron microscopy and high-speed video microscopy.
Primary ciliary dyskinesia (PCD) is a clinical syndrome that in dogs primarily manifests as chronic respiratory disease associated with cilial malfunction. The current study employs whole genome sequencing and a candidate gene approach to uncover the genetic basis of PCD in three Cocker spaniel siblings following diagnosis of their respiratory cilia by scanning electron microscopy and high-speed video microscopy.
the university of sydney