Comparative transcriptomic analysis of DDI2-deficient THP-1 cells vs Control THP-1 cells upon challenge with selective immunoproteasome inhibitor
Proteasome content in immune cells is comprised by mainly immunoproteasome. Proteasome activity in immune cells is essential not only for cell viability, but also immune functions. DDI2 is responsible for the activation of Nrf1-induced proteasome bounce back response in human cells. This study aims to investigate unique transcripts induced by DDI2 upon selective immunoproteasome inhibition in immune cells. Sequencing libraries were prepared using XXX kits and sequenced on Element AVITI. This dataset provides the foundational raw reads to identify DDI2-dependent genes in immune cells.
Proteasome content in immune cells is comprised by mainly immunoproteasome. Proteasome activity in immune cells is essential not only for cell viability, but also immune functions. DDI2 is responsible for the activation of Nrf1-induced proteasome bounce back response in human cells. This study aims to investigate unique transcripts induced by DDI2 upon selective immunoproteasome inhibition in immune cells. Sequencing libraries were prepared using XXX kits and sequenced on Element AVITI. This dataset provides the foundational raw reads to identify DDI2-dependent genes in immune cells.
Department of Immunobiology, University of Lausanne