Intrinsic Differences in Hamster and Mouse Macrophages Biology
Hamster (ham) and mouse (m) bone marrow-derived macrophages (BMDMs) exhibit differential susceptibility to microbial infections, including Leishmania donovani. We hypothesize that intrinsic biological differences between these rodent macrophages contribute to this variability and ultimately to disease progression. To investigate this, we performed RNA sequencing on ham- and mBMDMs collected at 24 hours and 3 days post-differentiation. This allowed us to evaluate temporal changes in gene expression within each BMDM system and identify host determinants that may influence the establishment of intracellular infection.
Hamster (ham) and mouse (m) bone marrow-derived macrophages (BMDMs) exhibit differential susceptibility to microbial infections, including Leishmania donovani. We hypothesize that intrinsic biological differences between these rodent macrophages contribute to this variability and ultimately to disease progression. To investigate this, we performed RNA sequencing on ham- and mBMDMs collected at 24 hours and 3 days post-differentiation. This allowed us to evaluate temporal changes in gene expression within each BMDM system and identify host determinants that may influence the establishment of intracellular infection.
European Bioinformatics Institute