Genotypes and phylogenetic analysis of human adenovirus in hospitalized pneumonia and influenza-like illness patients in Jiangsu Province, China (2013-2021)
Human adenovirus (HAdV) is common pathogens that cause various respiratory diseases. The genetic diversity of viruses caused by recombination is considered to be the main source of emerging outbreaks. The aim of this study is to explore the evolutionary relationship and recombination events of HADV genome in respiratory tract infections in Jiangsu province.Whole-genome sequencing (WGS) technology was used to sequence 66 patients with HAdV infection (37 with influenza-like illness (ILI) and 29 with pneumonia) from Jiangsu Province. Epidemiological analysis was performed on pneumonia and ILI patients infected with HAdV. Subsequently, phylogenetic, recombination, and nucleotide and amino acid identity analyses were performed.The WGS analysis reveals the evolutionary relationships and recombination events of HAdV strains in Jiangsu province, which is helpful to deepen the understanding of HAdV epidemiology and evolution.
Human adenovirus (HAdV) is common pathogens that cause various respiratory diseases. The genetic diversity of viruses caused by recombination is considered to be the main source of emerging outbreaks. The aim of this study is to explore the evolutionary relationship and recombination events of HADV genome in respiratory tract infections in Jiangsu province.Whole-genome sequencing (WGS) technology was used to sequence 66 patients with HAdV infection (37 with influenza-like illness (ILI) and 29 with pneumonia) from Jiangsu Province. Epidemiological analysis was performed on pneumonia and ILI patients infected with HAdV. Subsequently, phylogenetic, recombination, and nucleotide and amino acid identity analyses were performed.The WGS analysis reveals the evolutionary relationships and recombination events of HAdV strains in Jiangsu province, which is helpful to deepen the understanding of HAdV epidemiology and evolution.
Jiangsu Provincial Center for Disease Control and Prevention