A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance
We investigated neural populations mediating the effects of cagrilintide on energy balance in the dorsal vagal complex (DVC). Single-nucleus RNA sequencing and spatial transcriptomics were performed across mouse, rat, and macaque brainstem tissue. Treatment groups include diet-induced obese animals treated acutely or subchronically with cagrilintide or vehicle. The overarching aim was to identify and characterize the neuronal population showing the strongest and most sustained transcriptional response to treatment. Included in this ArrayExpress ID is the bulk-seq data for mouse and rat
We investigated neural populations mediating the effects of cagrilintide on energy balance in the dorsal vagal complex (DVC). Single-nucleus RNA sequencing and spatial transcriptomics were performed across mouse, rat, and macaque brainstem tissue. Treatment groups include diet-induced obese animals treated acutely or subchronically with cagrilintide or vehicle. The overarching aim was to identify and characterize the neuronal population showing the strongest and most sustained transcriptional response to treatment. Included in this ArrayExpress ID is the bulk-seq data for mouse and rat
European Bioinformatics Institute