RNA-seq for Graves' orbitopathy, Graves' disease and health control
This study investigates the molecular landscape of Graves' disease (GD) and its extrathyroidal manifestation, Graves' orbitopathy (GO), with a specific focus on the systemic impact of thyroid-stimulating hormone receptor (TSHR) signaling. While GD and GO are primarily characterized by peripheral autoimmunity, emerging evidence suggests these conditions involve neuroimmune crosstalk and central nervous system (CNS) alterations.  To bridge the gap between peripheral autoimmunity and central involvement, we performed bulk RNA sequencing on peripheral blood samples from a cohort including 20 Graves' orbitopathy patients, 20 Graves' disease patients (without orbitopathy), and 20 healthy controls.  Our analysis identifies TSHR as a critical molecular hub mediating interactions between peripheral immune cells and the CNS. By comparing the transcriptomic signatures across these three groups, we aim to characterize the systemic immune dysregulation unique to GO and GD.
This study investigates the molecular landscape of Graves' disease (GD) and its extrathyroidal manifestation, Graves' orbitopathy (GO), with a specific focus on the systemic impact of thyroid-stimulating hormone receptor (TSHR) signaling. While GD and GO are primarily characterized by peripheral autoimmunity, emerging evidence suggests these conditions involve neuroimmune crosstalk and central nervous system (CNS) alterations.  To bridge the gap between peripheral autoimmunity and central involvement, we performed bulk RNA sequencing on peripheral blood samples from a cohort including 20 Graves' orbitopathy patients, 20 Graves' disease patients (without orbitopathy), and 20 healthy controls.  Our analysis identifies TSHR as a critical molecular hub mediating interactions between peripheral immune cells and the CNS. By comparing the transcriptomic signatures across these three groups, we aim to characterize the systemic immune dysregulation unique to GO and GD.
European Bioinformatics Institute