Astaxanthin Alleviates Dexamethasone-Induced Intestinal Ferroptosis via Gut Microbiota-Derived Retinoic Acid: A Novel Mechanism Involving SLC7A11 Regulation by Lepagella muris
Oxidative stress and ferroptosis are pivotal in intestinal damage pathogenesis, yet the interplay between dietary antioxidants, gut microbiota, and ferroptosis regulation remains poorly understood.While astaxanthin (ASTA) is recognized for its antioxidant properties, its role in ferroptosis modulation through gut microbiota-derived metabolites has not been elucidated. Here, we pioneer a mechanistic investigation into how ASTA, combined with Lepagella muris colonization, synergistically combats oxidative stress in a dexamethasone (DEX)-induced intestinal injury model.
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