Gut microbiota remodeling by oral Spirulina hydrogel in collagen-induced arthritis mice
Rheumatoid arthritis (RA) is associated with gut barrier dysfunction and microbiota dysbiosis. We developed an oral Spirulina-based hydrogel (SP-gel) and evaluated its effects on gut microbiota in collagen-induced arthritis (CIA) mice. 16S rDNA amplicon sequencing was used to profile gut microbial composition, revealing that SP-gel enriches beneficial taxa (e.g., Muribaculaceae) and modulates short-chain fatty acid production. This study provides sequencing data on SP-gel's microbiota-regulating effects in RA models.
Rheumatoid arthritis (RA) is associated with gut barrier dysfunction and microbiota dysbiosis. We developed an oral Spirulina-based hydrogel (SP-gel) and evaluated its effects on gut microbiota in collagen-induced arthritis (CIA) mice. 16S rDNA amplicon sequencing was used to profile gut microbial composition, revealing that SP-gel enriches beneficial taxa (e.g., Muribaculaceae) and modulates short-chain fatty acid production. This study provides sequencing data on SP-gel's microbiota-regulating effects in RA models.
Zhejiang University School of Medicine