Epidemiological and Molecular Characterization of Multi-Drug Resistant Bloodstream Infections of Gram-Negative Bacteria Clinical Isolates in Ethiopia
Bloodstream infections are major causes of morbidity and mortality around the world. Alarmingly, gram-negative bacteria that produce beta-lactamase and carbapenemase are causes for the rapid global spread of multi-drug resistance (MDR), which significantly jeopardizes the efficacy of existing antimicrobial treatments. Therefore, the main objective of this research is to determine the microbial profile, antimicrobial susceptibility pattern, the magnitude of beta-lactamase and carbapenemase-producing gram-negative bacteria clinical isolates, the genomic diversity of  AMR and virulent genes their point mutation, plasmid gene, and disinfectant resistance genes of drug-resistant bacteria as well as their associated risk factors in bloodstream infection among patients admitted to Tikur Anbessa Specialized Hospital (TASH) in Ethiopia. Isolates were sequenced and genotyped for AMR and virulence by the Fleming Fund SeqAfrica project, a UK Aid funded initiative to strengthen AMR surveillance in Africa.
Bloodstream infections are major causes of morbidity and mortality around the world. Alarmingly, gram-negative bacteria that produce beta-lactamase and carbapenemase are causes for the rapid global spread of multi-drug resistance (MDR), which significantly jeopardizes the efficacy of existing antimicrobial treatments. Therefore, the main objective of this research is to determine the microbial profile, antimicrobial susceptibility pattern, the magnitude of beta-lactamase and carbapenemase-producing gram-negative bacteria clinical isolates, the genomic diversity of  AMR and virulent genes their point mutation, plasmid gene, and disinfectant resistance genes of drug-resistant bacteria as well as their associated risk factors in bloodstream infection among patients admitted to Tikur Anbessa Specialized Hospital (TASH) in Ethiopia. Isolates were sequenced and genotyped for AMR and virulence by the Fleming Fund SeqAfrica project, a UK Aid funded initiative to strengthen AMR surveillance in Africa.
the seqafrica consortium