Multi-omic analysis of DNA:RNA hybrid genotoxicity in S. cerevisiae
This study combines genome-wide DNA:RNA hybrid mapping (qDRIP-seq) with short and long read analysis of mutation accumulation (WGS) in hybrid-forming mutant lines. It also features mutational profiling of a model hybrid-forming gene (LYS2) in specific mutant backgrounds, together with control transcriptome analyses.
This study combines genome-wide DNA:RNA hybrid mapping (qDRIP-seq) with short and long read analysis of mutation accumulation (WGS) in hybrid-forming mutant lines. It also features mutational profiling of a model hybrid-forming gene (LYS2) in specific mutant backgrounds, together with control transcriptome analyses.
Institut Jacques Monod, CNRS, Universite Paris Cite