NPC culturomics
The nasopharynx constitutes a critical niche in the upper respiratory tract, harboring a diverse microbiota linked to nasopharyngeal carcinoma (NPC), the mechanistic roles of which remain poorly understood. Here we establish the Nasopharyngeal Mucosal and Tumor-resident Bacterial Catalog (NMTBC) that comprises 5,311 bacterial isolates representing 127 species, with 1,006 of them being fully sequenced and annotated, providing a comprehensive culturable resource facilitating mechanistic dissection of the nasopharyngeal microbiome.
The nasopharynx constitutes a critical niche in the upper respiratory tract, harboring a diverse microbiota linked to nasopharyngeal carcinoma (NPC), the mechanistic roles of which remain poorly understood. Here we establish the Nasopharyngeal Mucosal and Tumor-resident Bacterial Catalog (NMTBC) that comprises 5,311 bacterial isolates representing 127 species, with 1,006 of them being fully sequenced and annotated, providing a comprehensive culturable resource facilitating mechanistic dissection of the nasopharyngeal microbiome.
Sun Yat-sen University Cancer Center