TnSeq and RNAseq of Klebsiella pneumoniae in creek water
Klebsiella pneumoniae is a priority opportunistic pathogen that is found in soil, water and plant-associated niches as well as associated with humans. Host fitness factors of K. pneumoniae include a highly diverse polysaccharide capsule, siderophores and fimbriae, among others, however little is known about how this pathogen survives outside the host. We conducted genome-scale fitness screening to explore survival mechanisms of K. pneumoniae ATCC43816 in fresh water. Survival-related genes were compared to transcriptomics.
Klebsiella pneumoniae is a priority opportunistic pathogen that is found in soil, water and plant-associated niches as well as associated with humans. Host fitness factors of K. pneumoniae include a highly diverse polysaccharide capsule, siderophores and fimbriae, among others, however little is known about how this pathogen survives outside the host. We conducted genome-scale fitness screening to explore survival mechanisms of K. pneumoniae ATCC43816 in fresh water. Survival-related genes were compared to transcriptomics.
Monash University, Department of Microbiology