Nosocomial transmission of ESBL E. coli and K. pneumoniae
The high prevalence, clinical impact, and transmissibility of healthcare-associated multidrug-resistant Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) make them key targets for infection control strategies based on genomic surveillance. However, distinguishing nosocomial from community transmission, and understanding the dynamics of nosocomial spread, particularly interhospital transmission, remains challenging. To address these issues, we performed a comparative analysis using data from a prospective regional whole-genome sequencing (WGS) surveillance program of ESBL-producing E. coli and K. pneumoniae (ESBL EcKp) across five hospitals in the Netherlands. We investigated: (1) the relative contribution of nosocomial transmission to the overall spread of ESBL EcKp, (2) whether specific hospital departments were associated with increased risk of nosocomial transmission, and (3) evidence of interhospital transmission.
The high prevalence, clinical impact, and transmissibility of healthcare-associated multidrug-resistant Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) make them key targets for infection control strategies based on genomic surveillance. However, distinguishing nosocomial from community transmission, and understanding the dynamics of nosocomial spread, particularly interhospital transmission, remains challenging. To address these issues, we performed a comparative analysis using data from a prospective regional whole-genome sequencing (WGS) surveillance program of ESBL-producing E. coli and K. pneumoniae (ESBL EcKp) across five hospitals in the Netherlands. We investigated: (1) the relative contribution of nosocomial transmission to the overall spread of ESBL EcKp, (2) whether specific hospital departments were associated with increased risk of nosocomial transmission, and (3) evidence of interhospital transmission.
Elisabeth Tweesteden Ziekenhuis