Exploring dog brain cell transcriptomic diversity provides insight into domestication, behaviour, disease, and pharmacology
Domesticated dogs present a unique case in nature where mutualism with and selective breeding by humans has led to profound changes in their environment, physiology, and behaviour compared to their wolf-like ancestors. Dog tameness, sociability, and trainability have likely evolved due to significant alterations to brain function. Exploring the effects of domestication on the dog brain will be facilitated by the characterisation of dog brain cell diversity, a task which is not yet complete. To fill this gap, we use single-nucleus RNA sequencing and survey cell types across the dog brain. We present transcriptomes from almost 60,000 cells sampled from the cerebellum, thalamus, and three regions of the cerebrum. Our analysis identified 24 major clusters representing 21 broad cell types, and 131 subclusters revealing regional variation. Comparisons with human and mouse datasets revealed a high level of conservation in neurons across mammalian brains, and greater divergence in glial cells, particularly oligodendrocytes. We demonstrate the utility of the dataset for interrogating specific gene expression patterns across the brain, including genes implicated in dog domestication, behavioural traits, and disease. We discover distinct differences in the expression of opioid receptors in the brains of dogs, compared to humans and mice, providing a potential explanation for dogs' higher tolerance and lower risk of severe adverse effects of opioid drugs. The data from this project is released in a web application for use by the wider community.  The data in this project is snRNA-seq data generated by a combination of 10X genomics and Parse Biosciences protocols. The 10X data are per-sample fastq files, whereas the Parse Biosciences data are pooled multi-sample libraries. Well information required for processing the Parse files is included here: Biosample tissue_sample Wells Run_accessions SAMEA121801633 F1-1-occipital_cortex_Y B10 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-2-cerebellum_Y A12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-3-temporal_cortex_Y B1 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-4-frontal_lobe_Y B2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-5-liver D12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-6-thalamus_Y C4 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-9-Hypothalamus_Y C10 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-1-occipital_cortex-Y C1-C2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-2-cerebellum B3-B4 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-3-temporal_lobe B5-B6 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-4-frontal_lobe B7-B8 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-6-thalamus C7-C8 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-7-striatum_Y D5-D6 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-8-anterior_cingulate_gyrus_Y D9-D10 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-9-hypothalamus_Y D1-D2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-1-occipital_cortex_Y B9 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-2-cerebellum_Y A1 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-3-temporal_cortex_Y A2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-4-frontal_lobe_Y A3 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-6-thalamus_Y C3 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-9-hypothalamus_Y C9 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-1-occipital_cortex_N D11 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-1-occipital_cortex_Y B11-B12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-2-cerebellum A4-A7 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-3-temporal_cortex A8-A9 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-4-frontal_lobe A10-A11 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-6-thalamus C5-C6 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-7-striatum_Y D3-D4 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-8-anterior_cingulate_gyrus_Y D7-D8 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-9-hypothalamus_Y C11-C12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-13-midbrain-mega D4-D6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801633 F1-5-liver-mega F12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-1-occipital_cortex-mega G7-G8 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-10-amygdala-mega A4-A6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-11-hippocampus-mega A10-A12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-12-medulla_oblongata-mega C10-C12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-14-parietal_lobe-mega B4-B6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-15-piriform_cortex-mega H11-H12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-16-pons-mega B10-B12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-2-cerebellum-mega F6-F7 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-3-temporal_cortex-mega F10-F11 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-4-frontal_lobe-mega G3-G4 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-6-thalamus-mega G11-G12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-7-striatum-mega H7-H8 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-8-anterior_cingulate_gyrus-mega D10-D12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-9-hypothalamus-mega H3-H4 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801635 M1-13-midbrain-mega D1-D3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-1-occipital_cortex-mega G5-G6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-10-amygdala-mega A1-A3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-11-hippocampus-mega A7-A9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-12-medulla_oblongata-mega C7-C9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-14-parietal_lobe-mega B1-B3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-15-piriform_cortex-mega H9-H10 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-16-pons-mega B7-B9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-2-cerebellum-mega F4-F5 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-2-cerebellum-mega_M59 F1-F3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-3-temporal_cortex-mega F8-F9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-4-frontal_lobe-mega G1-G2 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-6-thalamus-mega G9-G10 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-7-striatum-mega H5-H6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-8-anterior_cingulate_gyrus-mega D7-D9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-9-hypothalamus-mega H1-H2 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801633 F1-1-occipital_cortex-mega F10-F12 ERR16784167, ERR16784169 SAMEA121801633 F1-13-midbrain-mega E5-E8 ERR16784167, ERR16784169 SAMEA121801634 F2-10-amygdala-mega A5-A8 ERR16784167, ERR16784169 SAMEA121801634 F2-11-hippocampus-mega B1-B4 ERR16784167, ERR16784169 SAMEA121801634 F2-12-medulla_oblongata-mega D9-D12 ERR16784167, ERR16784169 SAMEA121801634 F2-14-parietal_lobe-mega B9-B12 ERR16784167, ERR16784169 SAMEA121801634 F2-15-piriform_cortex-mega F1-F4 ERR16784167, ERR16784169 SAMEA121801634 F2-16-pons-mega C5-C8 ERR16784167, ERR16784169 SAMEA121801634 F2-8-anterior_cingulate_gyrus-mega H5-H12 ERR16784167, ERR16784169 SAMEA121801634 F2-9-hypothalamus-mega G9-G12 ERR16784167, ERR16784169 SAMEA121801635 M1-1-occipital_cortex-mega F5-F9 ERR16784167, ERR16784169 SAMEA121801635 M1-13-midbrain-mega E1-E4 ERR16784167, ERR16784169 SAMEA121801636 M2-10-amygdala-mega A1-A4 ERR16784167, ERR16784169 SAMEA121801636 M2-11-hippocampus-mega A9-A12 ERR16784167, ERR16784169 SAMEA121801636 M2-12-medulla_oblongata-mega D5-D8 ERR16784167, ERR16784169 SAMEA121801636 M2-14-parietal_lobe-mega B5-B8 ERR16784167, ERR16784169 SAMEA121801636 M2-15-piriform_cortex-mega E9-E12 ERR16784167, ERR16784169 SAMEA121801636 M2-16-pons-mega C1-C4 ERR16784167, ERR16784169 SAMEA121801636 M2-6-thalamus-mega G1-G8 ERR16784167, ERR16784169 SAMEA121801636 M2-7-striatum-mega H1-H4 ERR16784167, ERR16784169
Domesticated dogs present a unique case in nature where mutualism with and selective breeding by humans has led to profound changes in their environment, physiology, and behaviour compared to their wolf-like ancestors. Dog tameness, sociability, and trainability have likely evolved due to significant alterations to brain function. Exploring the effects of domestication on the dog brain will be facilitated by the characterisation of dog brain cell diversity, a task which is not yet complete. To fill this gap, we use single-nucleus RNA sequencing and survey cell types across the dog brain. We present transcriptomes from almost 60,000 cells sampled from the cerebellum, thalamus, and three regions of the cerebrum. Our analysis identified 24 major clusters representing 21 broad cell types, and 131 subclusters revealing regional variation. Comparisons with human and mouse datasets revealed a high level of conservation in neurons across mammalian brains, and greater divergence in glial cells, particularly oligodendrocytes. We demonstrate the utility of the dataset for interrogating specific gene expression patterns across the brain, including genes implicated in dog domestication, behavioural traits, and disease. We discover distinct differences in the expression of opioid receptors in the brains of dogs, compared to humans and mice, providing a potential explanation for dogs' higher tolerance and lower risk of severe adverse effects of opioid drugs. The data from this project is released in a web application for use by the wider community.  The data in this project is snRNA-seq data generated by a combination of 10X genomics and Parse Biosciences protocols. The 10X data are per-sample fastq files, whereas the Parse Biosciences data are pooled multi-sample libraries. Well information required for processing the Parse files is included here: Biosample tissue_sample Wells Run_accessions SAMEA121801633 F1-1-occipital_cortex_Y B10 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-2-cerebellum_Y A12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-3-temporal_cortex_Y B1 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-4-frontal_lobe_Y B2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-5-liver D12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-6-thalamus_Y C4 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-9-Hypothalamus_Y C10 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-1-occipital_cortex-Y C1-C2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-2-cerebellum B3-B4 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-3-temporal_lobe B5-B6 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-4-frontal_lobe B7-B8 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-6-thalamus C7-C8 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-7-striatum_Y D5-D6 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-8-anterior_cingulate_gyrus_Y D9-D10 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801634 F2-9-hypothalamus_Y D1-D2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-1-occipital_cortex_Y B9 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-2-cerebellum_Y A1 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-3-temporal_cortex_Y A2 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-4-frontal_lobe_Y A3 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-6-thalamus_Y C3 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801635 M1-9-hypothalamus_Y C9 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-1-occipital_cortex_N D11 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-1-occipital_cortex_Y B11-B12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-2-cerebellum A4-A7 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-3-temporal_cortex A8-A9 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-4-frontal_lobe A10-A11 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-6-thalamus C5-C6 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-7-striatum_Y D3-D4 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-8-anterior_cingulate_gyrus_Y D7-D8 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801636 M2-9-hypothalamus_Y C11-C12 ERR16779336,ERR16779337,ERR16779338,ERR16779339,ERR16779355,ERR16779744,ERR16779747,ERR16779750 SAMEA121801633 F1-13-midbrain-mega D4-D6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801633 F1-5-liver-mega F12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-1-occipital_cortex-mega G7-G8 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-10-amygdala-mega A4-A6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-11-hippocampus-mega A10-A12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-12-medulla_oblongata-mega C10-C12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-14-parietal_lobe-mega B4-B6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-15-piriform_cortex-mega H11-H12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-16-pons-mega B10-B12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-2-cerebellum-mega F6-F7 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-3-temporal_cortex-mega F10-F11 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-4-frontal_lobe-mega G3-G4 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-6-thalamus-mega G11-G12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-7-striatum-mega H7-H8 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-8-anterior_cingulate_gyrus-mega D10-D12 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801634 F2-9-hypothalamus-mega H3-H4 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801635 M1-13-midbrain-mega D1-D3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-1-occipital_cortex-mega G5-G6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-10-amygdala-mega A1-A3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-11-hippocampus-mega A7-A9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-12-medulla_oblongata-mega C7-C9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-14-parietal_lobe-mega B1-B3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-15-piriform_cortex-mega H9-H10 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-16-pons-mega B7-B9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-2-cerebellum-mega F4-F5 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-2-cerebellum-mega_M59 F1-F3 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-3-temporal_cortex-mega F8-F9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-4-frontal_lobe-mega G1-G2 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-6-thalamus-mega G9-G10 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-7-striatum-mega H5-H6 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-8-anterior_cingulate_gyrus-mega D7-D9 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801636 M2-9-hypothalamus-mega H1-H2 ERR16781892,ERR16781901,ERR16782001,ERR16782096,ERR16782098,ERR16782100,ERR16782104,ERR16782108,ERR16782110,ERR16782116 SAMEA121801633 F1-1-occipital_cortex-mega F10-F12 ERR16784167, ERR16784169 SAMEA121801633 F1-13-midbrain-mega E5-E8 ERR16784167, ERR16784169 SAMEA121801634 F2-10-amygdala-mega A5-A8 ERR16784167, ERR16784169 SAMEA121801634 F2-11-hippocampus-mega B1-B4 ERR16784167, ERR16784169 SAMEA121801634 F2-12-medulla_oblongata-mega D9-D12 ERR16784167, ERR16784169 SAMEA121801634 F2-14-parietal_lobe-mega B9-B12 ERR16784167, ERR16784169 SAMEA121801634 F2-15-piriform_cortex-mega F1-F4 ERR16784167, ERR16784169 SAMEA121801634 F2-16-pons-mega C5-C8 ERR16784167, ERR16784169 SAMEA121801634 F2-8-anterior_cingulate_gyrus-mega H5-H12 ERR16784167, ERR16784169 SAMEA121801634 F2-9-hypothalamus-mega G9-G12 ERR16784167, ERR16784169 SAMEA121801635 M1-1-occipital_cortex-mega F5-F9 ERR16784167, ERR16784169 SAMEA121801635 M1-13-midbrain-mega E1-E4 ERR16784167, ERR16784169 SAMEA121801636 M2-10-amygdala-mega A1-A4 ERR16784167, ERR16784169 SAMEA121801636 M2-11-hippocampus-mega A9-A12 ERR16784167, ERR16784169 SAMEA121801636 M2-12-medulla_oblongata-mega D5-D8 ERR16784167, ERR16784169 SAMEA121801636 M2-14-parietal_lobe-mega B5-B8 ERR16784167, ERR16784169 SAMEA121801636 M2-15-piriform_cortex-mega E9-E12 ERR16784167, ERR16784169 SAMEA121801636 M2-16-pons-mega C1-C4 ERR16784167, ERR16784169 SAMEA121801636 M2-6-thalamus-mega G1-G8 ERR16784167, ERR16784169 SAMEA121801636 M2-7-striatum-mega H1-H4 ERR16784167, ERR16784169
Uppsala University