beta-Glucan mitigates necrotizing enterocolitis-induced long-term cognitive impairment: shotgun metagenomic sequencing of mouse fecal microbiota reveals reshaped gut microbiota and restored tryptophan-IAA gut-brain signaling
We performed shotgun metagenomic sequencing on fecal samples from C57BL/6 mouse necrotizing enterocolitis (NEC) model animals with or without beta-glucan intervention and FMT treatment. This dataset investigates how beta-glucan remodels gut microbiota, restores tryptophan metabolite indole-3-acetic acid (IAA)-dependent gut-brain signaling, and alleviates long-term cognitive impairment induced by NEC. Raw metagenomic paired-end fastq reads are deposited in SRA.
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