Gel-Forming Fibres and Inulin Fermentation
This study investigates how gel-forming dietary fibres, specifically psyllium and methylcellulose, influence the fermentation of inulin in an in vitro colonic model. Using faecal inocula from healthy donors, we compared fermentation kinetics, metabolite production, microbial community composition, and microbial localisation within fibre gels. The study further assessed the bioactivity of fermentation products on gut neuroendocrine signalling using STC-1 cells. Findings aim to elucidate how fibre gelation modulates microbial access to substrates and drives metabolic and hormonal responses relevant to gastrointestinal health and irritable bowel syndrome.
This study investigates how gel-forming dietary fibres, specifically psyllium and methylcellulose, influence the fermentation of inulin in an in vitro colonic model. Using faecal inocula from healthy donors, we compared fermentation kinetics, metabolite production, microbial community composition, and microbial localisation within fibre gels. The study further assessed the bioactivity of fermentation products on gut neuroendocrine signalling using STC-1 cells. Findings aim to elucidate how fibre gelation modulates microbial access to substrates and drives metabolic and hormonal responses relevant to gastrointestinal health and irritable bowel syndrome.
Quadram Institute Bioscience