RNASeq____Characterising_smoking_effects_on_the_AhR_pathway
The aim of this study is to investigate the mechanisms of the increased mutation burden induced by smoking related mutagens (e.g. Benzo-a-pyrene). We use several mouse models with Knock-out of the AhR gene and CYP enzymes to study the driving force of mutation burden and the changes in detoxification pathways in airway epithelial cells.
The aim of this study is to investigate the mechanisms of the increased mutation burden induced by smoking related mutagens (e.g. Benzo-a-pyrene). We use several mouse models with Knock-out of the AhR gene and CYP enzymes to study the driving force of mutation burden and the changes in detoxification pathways in airway epithelial cells.
Wellcome Sanger Institute