Cross-resistance to carbamates and pyrethroids
Malaria vectors have become intensely resistant to pyrethroid insecticides, jeopardizing control efforts. Managing this resistance requires understanding potential cross-resistance mechanisms with other classes of insecticides. Here, we demonstrate that the tandemly duplicated cytochrome P450 genes CYP6P4a/b and their respective M220I and D284E variants confer cross-resistance to both carbamates and pyrethroids in west African populations of the malaria vector Anopheles funestus from Ghana.
Malaria vectors have become intensely resistant to pyrethroid insecticides, jeopardizing control efforts. Managing this resistance requires understanding potential cross-resistance mechanisms with other classes of insecticides. Here, we demonstrate that the tandemly duplicated cytochrome P450 genes CYP6P4a/b and their respective M220I and D284E variants confer cross-resistance to both carbamates and pyrethroids in west African populations of the malaria vector Anopheles funestus from Ghana.
Centre for Research in Infectious Diseases