Transcriptome of the brain of largemouth bass infected with Micropterus salmoides rhabdovirus (MSRV)
Micropterus salmoides (largemouth bass) is an economically significant freshwater fish that faces serious threats from various pathogens. Micropterus salmoides rhabdovirus (MSRV) is a pathogenic virus that primarily infects juvenile fish, leading to severe disease. Although some studies have reported the transcriptome sequencing of immune-related tissues in Micropterus salmoides after MSRV infection, studies focusing on central nervous system remain scarce. In this study, largemouth bass juvenile fish were infected by intraperitoneal injection of MSRV. Severe external clinical sign, together with high virus load were detected in brain tissue after MSRV infection. Transcriptomic analysis showed that the expression level of 658 genes (297 up-regulated genes and 361 down-regulated) in brain tissues was significantly altered.
BioProject