Changes in nasal and oral microbiota composition during a ten-day decolonization course with mupirocin and povidone-iodine: A real-world case series
Colonization with Staphylococcus aureus including methicillin-resistant S. aureus (MRSA) is a major risk factor for subsequent infection (1). To reduce the risk of infection decolonization protocols have been developed (1). However, effectiveness varies across studies, and growing evidence suggests that the microbiome influences colonization status (2, 3). In one out of four colonized individuals MRSA is detected solely in the throat (4), and throat colonization has been identified a risk-factor for decolonization failure (2). Recent studies have explored the use of probiotics for decolonization, underscoring the role of microbiota in colonization, providing valuable insights in potential new treatment strategies (1, 5). However, little is known about oral microbiota dynamics in adults undergoing decolonization, particularly when povidone-iodine (PVP-I) is used for the oral cavity. A better understanding of microbiota shifts might help to overcome limitations of current decolonization strategies eventually. We report descriptive longitudinal microbiological findings from a case series of three patients who underwent a ten-day decolonization with PVP-I and were exclusively colonized in the throat.
Colonization with Staphylococcus aureus including methicillin-resistant S. aureus (MRSA) is a major risk factor for subsequent infection (1). To reduce the risk of infection decolonization protocols have been developed (1). However, effectiveness varies across studies, and growing evidence suggests that the microbiome influences colonization status (2, 3). In one out of four colonized individuals MRSA is detected solely in the throat (4), and throat colonization has been identified a risk-factor for decolonization failure (2). Recent studies have explored the use of probiotics for decolonization, underscoring the role of microbiota in colonization, providing valuable insights in potential new treatment strategies (1, 5). However, little is known about oral microbiota dynamics in adults undergoing decolonization, particularly when povidone-iodine (PVP-I) is used for the oral cavity. A better understanding of microbiota shifts might help to overcome limitations of current decolonization strategies eventually. We report descriptive longitudinal microbiological findings from a case series of three patients who underwent a ten-day decolonization with PVP-I and were exclusively colonized in the throat.
University of Zurich