Comparative transcriptomic responses of bank vole kidney and respiratory epithelial cells to distinct orthohantaviruses
Orthohantaviruses are rodent-borne viruses that can cause severe disease in humans but remain asymptomatic in their natural hosts. Increasing outbreaks and ecological changes raise important public health concerns. Understanding how these viruses interact with host cells is essential, particularly in reservoir species. Using RNA sequencing, the study compares cellular responses to different orthohantaviruses in bank vole kidney and respiratory cells. The results identify shared and virus- or tissue-specific regulatory factors linked to infection outcomes. Note that biological material originates from immortalized epithelial cell lines derived from bank vole (Myodes glareolus, NCBI Taxonomy ID: 447135). Mus musculus was selected in controlled vocabulary fields due to repository limitations and because mouse orthologs were used for functional annotation.
Orthohantaviruses are rodent-borne viruses that can cause severe disease in humans but remain asymptomatic in their natural hosts. Increasing outbreaks and ecological changes raise important public health concerns. Understanding how these viruses interact with host cells is essential, particularly in reservoir species. Using RNA sequencing, the study compares cellular responses to different orthohantaviruses in bank vole kidney and respiratory cells. The results identify shared and virus- or tissue-specific regulatory factors linked to infection outcomes. Note that biological material originates from immortalized epithelial cell lines derived from bank vole (Myodes glareolus, NCBI Taxonomy ID: 447135). Mus musculus was selected in controlled vocabulary fields due to repository limitations and because mouse orthologs were used for functional annotation.
European Bioinformatics Institute