RNA-Seq of hCMECs treated with RS218
This project investigates the early transcriptional response of human cerebral microvascular endothelial cells (hCMECs) upon infection with the neonatal meningitis-causing ExPEC strain RS218. RNA-seq was performed 2 hours post-infection to identify host gene expression changes involved in blood-brain barrier disruption, inflammation, and innate immune activation. These data provide insights into the endothelial response to ExPEC invasion during the early phase of infection.
This project investigates the early transcriptional response of human cerebral microvascular endothelial cells (hCMECs) upon infection with the neonatal meningitis-causing ExPEC strain RS218. RNA-seq was performed 2 hours post-infection to identify host gene expression changes involved in blood-brain barrier disruption, inflammation, and innate immune activation. These data provide insights into the endothelial response to ExPEC invasion during the early phase of infection.
Southwest University