Macrophage?intestinal organoid co-culture model captures balanced epithelial homeostasis and inflammation
Bulk RNA-seq study of murine intestinal organoids co-cultured with bone marrow-derived macrophages (BMDMs) at two macrophage densities (1,000 and 5,000 cells), with or without TNF?? stimulation, alongside organoid-only and BMDM-only controls. The study identifies transcriptional programs underlying epithelial homeostasis and inflammatory responses driven by macrophage?organoid interactions.
Bulk RNA-seq study of murine intestinal organoids co-cultured with bone marrow-derived macrophages (BMDMs) at two macrophage densities (1,000 and 5,000 cells), with or without TNF?? stimulation, alongside organoid-only and BMDM-only controls. The study identifies transcriptional programs underlying epithelial homeostasis and inflammatory responses driven by macrophage?organoid interactions.
Jeju National University