Examining the effect of SMARCA4–p53 regulatory axis on SCCOHT cells transcription
To examine the role SMARCA4-p53 regulatory axis in SCCOHT cells we performed RNA-seq in BIN-67 cells with SMARCA4 restoration, p53ko alone or combined with SMARCA4 and idasanutlin treatment (0.5µM, 24h) which increase the stability of p53 and its protein levels in SCCOHT.
To examine the role SMARCA4-p53 regulatory axis in SCCOHT cells we performed RNA-seq in BIN-67 cells with SMARCA4 restoration, p53ko alone or combined with SMARCA4 and idasanutlin treatment (0.5µM, 24h) which increase the stability of p53 and its protein levels in SCCOHT.
European Bioinformatics Institute