Urine and gut microbiome in patients with urolithiasis versus BPH controls
The gut microbiome has been implicated in urolithiasis pathogenesis, acting through mechanisms including oxalate metabolism and intestinal barrier regulation. However, functional microbiome characteristics associated with stone formation remain poorly understood. To address this knowledge gap, we characterized gut and urinary microbiome profiles and their functional signatures in urolithiasis and non-stone control patients.This prospective observational study enrolled 39 male patients scheduled for elective surgery: 21 with urolithiasis (stone group) and 18 with benign prostatic hyperplasia (control group). Paired stool and urine samples were collected and subjected to 16S rRNA gene sequencing.
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