Whole-genome sequencing of serum-resistance heterogeneous subpopulations of Klebsiella pneumoniae KP34537
This project contains whole-genome sequencing data for two clonally related phenotypic subpopulations, designated H and L, derived from Klebsiella pneumoniae strain KP34537. The H subpopulation exhibits a translucent, low-capsule, serum-resistant phenotype, whereas the L subpopulation exhibits an opaque, higher-capsule, serum-sensitive phenotype. Comparative genomic analysis was performed to identify genetic differences associated with this within-strain heterogeneity and to investigate the genetic basis of altered capsule production and serum resistance. The representative H isolate carries a disruptive wcaJ variant, whereas the L isolate retains an intact wcaJ locus. These data provide a genomic basis for investigating the emergence and selection of serum-resistant variants within a clonal K. pneumoniae population.