Early life high-fat diet exposure modulates adult metabolic phenotypes in Drosophila
We test whether a larval high-fat diet imprints adult metabolism in Drosophila melanogaster. Adult head and fat body were profiled by RNA-seq, and gut microbiota. The goals are to define tissue-specific transcriptional effects, map mitochondrial/redox and microbiota pathways, derive cross-omic modules, and release a reusable dataset. The relevance is in cleanly probing developmental programming, exposing conserved mitochondria-redox-microbiota axes, and providing a public benchmark to guide analysis and therapeutic target discovery.