Placental mRNA Sequencing Reveals Protective Effects of Metformin in a PCOS mouse model
Polycystic ovary syndrome (PCOS) increases the risk of pregnancy complications and predisposes offspring to long-term reproductive and metabolic disorders. The placenta plays a key role in mediating these developmental programming effects. This study investigates how metformin modulates placental molecular pathways in a PCOS context. A PCOS-like mouse model was induced with dehydroepiandrosterone (DHEA) and divided into control, DHEA, and DHEA+metformin groups. Normal embryos generated via in vitro fertilization were transferred into recipient females. Placental tissues were collected at late gestation E18.5 for RNA squencing.