KSHV transgenic mice (d501)
Viruses contribute to the development of 15-20% of all human cancers. Yet, our understanding remains limited. For cancers caused by herpesviruses, such as Kaposi sarcoma-associated herpesvirus (KSHV), no therapies exist that target the virus. Mice that carry the entire KSHV genome except the essential reactivation and transcription activator (Rta/orf50) develop Kaposi sarcoma that is indistinguishable from human KS in pathology, histology, and transcription of both viral and host genes. These are the bulk RNAseq data from these tumors