Define the role of chromosome 17q gain in neuroblastoma malignancy
This study examines the molecular consequences of chromosome 17q gain in human neuroblastoma in the presence of MYCN amplification. Tumor samples derived from orthotopically implanted human embryonic stem cell line WA07 (H7; approval# NIHhESC-10-0061) containing MYCN overexpression, with or without the presence of chromosome 17q gain, were analyzed using bulk RNA sequencing to identify transcriptome regulation patterns associated with 17q gain. This data is made available through dbGaP. The study finds that 17q gain is linked to distinct transcriptional signatures and pathways implicated in tumor progression, and that specific genes located on chromosome 17q can accelerate tumorigenesis in vivo, including genes BIRC5, BRIP1, CBX2, CDC6, IGF2BP1, and TK1.