RNA-seq of MDMWGK-treated HUVECs
To elucidate the pro-angiogenic mechanism of the Spirulina-derived peptide MDMWGK, we performed transcriptome sequencing on HUVECs across three groups: control, VRI-induced vascular injury model, and VRI plus MDMWGK treatment. Differential gene expression and KEGG pathway enrichment analyses were conducted to identify key signaling cascades. Our findings demonstrate that MDMWGK activates the VEGFA/PI3K-Akt axis, highlighting its potential as a therapeutic candidate for ischemic vascular diseases.