BAZ1A Tunes SREBP1-dependent Transcription Machinery to Ferroptosis Resistance in ccRCC
As a lethal disease, clear cell renal cell carcinoma (ccRCC) is characterized by intracellular lipid droplet (LDs) accumulation. However, the underlying mechanisms and translational significance of LDs remain unclear. Based on an unbiased siRNA screen of bromodomain-containing epigenetic regulators, which play an essential role in tumorigenesis, we identified Bromodomain Adjacent to Zinc Finger Domain 1A (BAZ1A) as an essential gene for ccRCC tumor development. High BAZ1A and SREBP1 drive the enhancer-promoter interaction to facilitate the recruitment of cohesin subunit (SMAC1a), thus stimulating pro-lipogenic genes. Therefore, we utilized CUT&amp;Tag-seq to describe the epigenetic functions of BAZ1A in ccRCC cell lines.