Identification of IGF1R/STAT3/BBOX1 axis in murine IGF1R+ TPCs.
In this study, we performed CUT&amp;Tag-seq and ATAC-seq to characterize the STAT3-mediated epigenetic programs activated by IGF1R signaling in mouse Igf1r+ pericytes. Using these high-throughput sequencing approaches, we further delineated the biological mechanisms underlying the aberrant upregulation of carnitine in pericytes.