GLI2-associated Wnt-BMP activation is a targetable vulnerability in drug-tolerant oncogene-addicted lung cancer
This study investigates transcriptional adaptations associated with drug-tolerant persistence in oncogene-addicted non-small cell lung cancer. Bulk RNA sequencing and single-cell RNA sequencing were performed in ALK-rearranged H3122 cells exposed to alectinib at different stages of treatment and during subsequent lorlatinib treatment. The datasets were generated to characterize transcriptional programs associated with drug tolerance and resistance, with particular focus on Wnt, BMP/TGF-beta, Hedgehog, and Notch signaling pathways.