Genomic analysis and evaluation of the bioactivities of Xenorhabdus stockiae
This project focuses on the whole-genome sequencing and pangenomic analysis of newly isolated Xenorhabdus strains from Thailand to uncover novel biosynthetic gene clusters (BGCs). Xenorhabdus species are known to produce bioactive secondary metabolites with strong antimicrobial and cytotoxic properties. By analyzing their full genomes, we aim to investigate the diversity of these natural product BGCs. Additionally, the study evaluates the inhibitory activities of crude and fractionated bacterial extracts against clinically relevant pathogenic bacteria and human cancer cell lines. Ultimately, this research aims to bridge the gap between genomic potential and biological application for the discovery of novel antibiotics and anti-cancer therapeutics.