Application of preclinical drug screening using treatment-naive gastroesophageal  cancer patient-derived organoids
The goal of this study is to generate and characterise 3D patient-derived organoids (PDOs) from biopsy samples of treatment-naive gastric cancer GC and OEC patients. RNA-seq and whole exome sequencing was performed to identify actionable targets from the genomic and transcriptomic landscape of the PDOs to highlight the translatability of precision medicine.