16S rRNA data of fecal samples in the Wenzhou Parkinson's disease cohort
To discriminate the fecal 16S rRNA profiles between Parkinsons disease (PD) and healthy controls (HC) in Wenzhou, China, we analyzed a cohort comprising 102 patients diagnosed with idiopathic PD and 84 HC participants. Fecal samples were collected from all subjects, followed by DNA extraction and 16S rRNA gene amplicon sequencing. Each participant provided either over 1 g of fresh stool using a sterile disposable sampling kit or over 1 mL of fecal suspension preserved in 5 mL of nucleic acid stabilization buffer. All samples were transferred to minus 80 C storage within two hours of collection to ensure integrity for downstream microbiota sequencing.