Resistome and virulome analysis of NDM producing E. coli strains isolated from community acquired urinary tract infection
Urinary tract infections (UTIs) are the most common bacterial infection globally, contributing significantly to morbidity across all age groups. E. coli has long been recognized as a leading cause of hospital- and community-acquired urinary tract infections (CA-UTIs) due to its adaptability and presence within the human gastrointestinal tract. The emergence of carbapenemase-producing E. coli, particularly those harbouring New Delhi metallo-beta-lactamase (NDM) variants, has reshaped the epidemiological and clinical landscape of UTIs. The NDM gene, first identified in the Indian subcontinent, has now been widely disseminated across Asia and worldwide, posing a serious threat to public health and clinical management