Single-cell transcriptomic profiling of metastatic and non-metastatic lung adenocarcinoma
This study aimed to characterize the cellular composition and transcriptional heterogeneity of the tumor microenvironment in lung adenocarcinoma. Single-cell RNA sequencing was performed on primary tumor tissues obtained from patients with or without Description metastasis. Comparative analyses were conducted to identify cell populations, molecular pathways, and intercellular communication networks associated with metastatic progression, with particular attention to tumor-immune interactions and neutrophil-related signaling. These data provide a resource for understanding the cellular and molecular mechanisms underlying lung adenocarcinoma metastasis and for identifying potential therapeutic targets.