Hydrogen-producing capsules in the regulation of the microbiota in intestinal damage caused by bacterial infection
We further an ingestible hydrogen-producing capsule (HPC) that incorporates a miniaturized heterogeneous catalytic system safely encapsulated within a medical-grade polydimethylsiloxane (PDMS) shell. The capsule achieved sustained H2 release for approximately 20 h with concurrent release of trace amounts of formic acid. To evaluate its impact on gut microbiota regulation, an E. coli-induced intestinal injury model was established. Treatment with the capsule significantly suppressed the growth of pathogenic bacteria, restored gut microbial homeostasis, and facilitated intestinal barrier recovery