Mus musculus Epigenomics
As the most common monogenic heart disease, hypertrophic cardiomyopathy (HCM) is one of the main culprits of sudden death among young people. Gene mutation has long been considered as the sole mechanism in the pathogenesis of HCM, however, the contribution of epigenetic modification in HCM is still unclear. we analyzed the genome-wide DNA methylation using Infinium Human MethylationEPIC BeadChip arrays in IVS tissues from the HCM patients (n=79) and control donors (n=5). Our findings uncovered global reduction of DNA methylation in human HCM myocardial tissues, which may be a universal phenomenon in HCM population, and suggested that intervention targeting key genes related to DNA methylation defects may open new avenue for HCM therapy in the future.