CUT-Tag was performed on mouse primary VSMCs to explore the regulatory targets of NKRF.
Abdominal aortic aneurysm (AAA) is a common life-threatening vascular disease in humans, involving multiple complex pathophysiological mechanisms. As a transcriptional repressor, NF-kB repressing factor (NKRF) regulates the expression of various target genes and has been confirmed to play important roles in multiple disease models, such as post-myocardial infarction cardiac remodeling, inflammatory diseases, and tumors. However, the specific role of NKRF in vascular remodeling-related diseases like AAA remains unclear to date. In this study, we systematically verified the role and molecular mechanism of NKRF in the occurrence and development of AAA through CUT-Tag. CUT-Tag was performed on mouse primary VSMCs to explore the regulatory targets of NKRF.