Longitudinal full-length 16S rRNA gene sequencing of the vaginal microbiota in women with refractory bacterial vaginosis following Lactobacillus crispatus LC-RSL01 intervention
This project investigates longitudinal changes in the vaginal microbiota of women with refractory bacterial vaginosis enrolled in a prospective, randomized, placebo-controlled pilot study of intravaginal Lactobacillus crispatus LC-RSL01. Vaginal swab samples were collected at baseline and during follow-up menstrual cycles. Full-length 16S rRNA gene sequencing was performed to characterize changes in vaginal microbial community composition and the relative abundance of Lactobacillus crispatus following intervention.