Biological characterization and lytic spectrum analysis of porcine pathogenic Escherichia coli phage vB_EcoP_SD29
To address the impact of Escherichia coli on swine herds, this study focuses on the biological characterization and lytic spectrum analysis of the porcine pathogenic E. coli phage vB_EcoP_SD29. Given that antibiotic resistance poses a serious threat to the healthy development of the swine industry, phage therapy is considered one of the most promising alternative strategies. By systematically elucidating the host recognition mechanism, genomic safety, and in vivo proliferation dynamics of this phage, this study aims to provide core germplasm resources for the development of specific phage cocktail formulations against porcine bacterial diarrhea. This work supports the goal of reducing and replacing antibiotic use in livestock production, thereby contributing to food safety and public health.