Mitochondrial membrane lipid cardiolipin controls fiber-type adaptations in ageing muscle via ERR?
This project investigates how aging impacts mitochondrial health and function in skeletal muscle. We will compare young and old muscle samples to identify age-related changes in mitochondrial pathways, focusing on differences between oxidative and glycolytic muscle. By profiling mRNA expression, we aim to uncover molecular mechanisms underlying mitochondrial decline with age and muscle-type–specific vulnerabilities, providing insight into skeletal muscle aging and its contribution to functional decline.
This project investigates how aging impacts mitochondrial health and function in skeletal muscle. We will compare young and old muscle samples to identify age-related changes in mitochondrial pathways, focusing on differences between oxidative and glycolytic muscle. By profiling mRNA expression, we aim to uncover molecular mechanisms underlying mitochondrial decline with age and muscle-type–specific vulnerabilities, providing insight into skeletal muscle aging and its contribution to functional decline.