BRCA1 and BRCA2 among small cohort of familial and non-familial BC women using next-generation sequencing
Knowledge about genetic predisposition among Egyptian cancer patients and its clinical relevance is inadequate. Therefore, this study investigated the presence of genetic mutations in BRCA1 and BRCA2 among familial and non-familial BC women using next-generation sequencing in addition to its possible relation with clinicopathological parameters like tumor grade and hormonal receptor. Moreover, oncogenic viruses, HPV and HMTV, were screened to test if they modulate outcomes of BRCA1 and BRCA2 mutations in the Egyptian population.