Kharituwe: A pragmatic RCT trial of TB household contact investigation at two sites in South Africa
In an effort to find evidence-based strategies to improve TB household contact investigation yield, Kharituwe (Let's go in isiVenda) aimed to evaluate two novel strategies for the timing of household contact investigation in South Africa. The study compared standard contact investigation conducted during regular business hours to contact investigation conducted in early evenings and on weekends in an urban setting and during three annual holiday periods in a rural setting. As part of the study, WGS was conducted on sputum culture isolates from participants (both index cases and household contacts) with culture-positive TB.