Transcriptomic profiling of neonatal rat cardiomyocytes after OGD/R injury and endothelial exosome delivery
Four experimental groups were analyzed: Control, OGD/R, DNPCAC, and DNPCAC-EXO, with three biological replicates per group. DNPCAC is an engineered nanosystem designed for endothelial cell-derived exosome capture and delivery, whereas DNPCAC-EXO represents DNPCAC associated with endothelial cell-derived exosomes. The transcriptomic dataset was generated to investigate gene-expression changes associated with OGD/R-induced cardiomyocyte injury and the cardioprotective effects of endothelial exosome delivery, with particular attention to cell-survival, stress-response, cytoskeletal, and sarcomeric programs.