RNA-seq of human Peripheral blood mononuclear cells (PBMCs) from COVID-19 patients requiring different degree of respiratory support
To identify possible deregulated pathways involved in COVID-19 severity, we analyzed the transcriptomic profiles of 59 patients affected by severe COVID-19 symptoms, comparing those who were only hospitalized and required supplemental oxygen support (N=24) with those who were also admitted to the ICU and received more intensive respiratory support, such as non-invasive ventilation or ventilator support (N=35, critically severe).
To identify possible deregulated pathways involved in COVID-19 severity, we analyzed the transcriptomic profiles of 59 patients affected by severe COVID-19 symptoms, comparing those who were only hospitalized and required supplemental oxygen support (N=24) with those who were also admitted to the ICU and received more intensive respiratory support, such as non-invasive ventilation or ventilator support (N=35, critically severe).