Urinary Cell RNA Editing Profiles in Prostate Acinar Adenocarcinoma
This study profiles RNA editing events in urinary sediment cells from individuals with prostate acinar adenocarcinoma and non-cancer controls. RNA sequencing data were used to characterize global and site-specific RNA editing patterns, identify differentially edited sites and associated genes, and investigate their functional relationships with tumor-related pathways. The study also evaluates whether urinary RNA editing signatures, alone or combined with serum prostate-specific antigen (PSA), can support the noninvasive detection of prostate acinar adenocarcinoma, including in individuals with PSA values in the diagnostic gray zone.