Genomic microdiversity of Mycobacterium africanum in Sénégal
Mycobacterium africanum responsible for up to half of tuberculosis cases in West Africa comprises of four sublineages. Its genomic diversity remains undescribed in its birthplace, Sénégal where present study was conducted. Our results offer new perspectives on the phylogenetic diversity and antimicrobial resistance of M. africanum in Senegal. The emerging drug resistant forms and the discrepancies between DST and whole genome sequencing highlight the importance of genomic surveillance for an effective tuberculosis control in this country.
Mycobacterium africanum responsible for up to half of tuberculosis cases in West Africa comprises of four sublineages. Its genomic diversity remains undescribed in its birthplace, Sénégal where present study was conducted. Our results offer new perspectives on the phylogenetic diversity and antimicrobial resistance of M. africanum in Senegal. The emerging drug resistant forms and the discrepancies between DST and whole genome sequencing highlight the importance of genomic surveillance for an effective tuberculosis control in this country.