Evolution of S. aureus resistance to a Rountreeviridae phage
Whole-genome sequencing of Staphylococcus aureus ST1 clinical isolate SA436rcpcm samples collected at different time points during independent co-cultivation experiments with the virulent phage vB_SauP-436A1 (Rountreeviridae), together with individual bacteriophage-insensitive mutant (BIM) clones isolated from the 24-h samples. BIM clones were purified by three successive colony passages prior to sequencing. The data are used to identify genomic mutations associated with the emergence and development of phage resistance.