Gasdermin E acts as a rheostat to determine survival from caspase activation and consequent mutagenesis
Gasdermin E is a pore forming protein that hastens cell death when caspases are activated. We found that tumor cell expression of Gasdermin E affects their ability to resist and recover from chemotherapeutics and cytotoxic cell attacks. One consequence of which is the accumulation of mutations in progeny of cells that have survived and proliferated.