Transcriptome sequencing of mouse colonic tissues reveals the molecular mechanisms underlying curcumol treatment in DSS-induced ulcerative colitis
This project generated transcriptomic profiles of mouse colonic tissues to investigate the molecular mechanisms of curcumol in the treatment of dextran sulfate sodium (DSS)-induced ulcerative colitis. C57BL/6J mice were divided into control, DSS-induced colitis, and curcumol-treated groups. RNA sequencing was performed on colonic tissues collected from four biological replicates per group using the Illumina NovaSeq 6000 platform. Differential expression analysis and pathway enrichment analysis were conducted to identify transcriptomic alterations associated with disease induction and curcumol intervention. These data provide insights into host gene expression changes involved in the therapeutic effects of curcumol against ulcerative colitis.