Lethal viral sepsis/septic shock in Getah virus infected Ifnar1-/- mice
RNA-Seq of spleens from GETV infected Ifnar1-/- mice illustrated a cytokine storm response that included robust type I interferon signatures and a pattern of cytokine/chemokine signatures indicative of viral sepsis/septic shock. Ifnar1-/- mice thus offer a framework for understanding, and a mouse model for, GETV disease in piglets. The model also predicts that lethal GETV infection in piglets involves viral sepsis/septic shock.