Genetic landscape features associated with PD-L1 expression status in advanced lung adenocarcinoma: a targeted sequencing analysis
In this study, we performed targeted next-generation sequencing (NGS) of tumor tissue DNA from 84 patients with advanced lung adenocarcinoma using a hybridization capture-based panel covering 95 cancer-associated genes. We systematically characterized the differences in somatic mutation spectra, driver gene co-occurrence/mutual exclusivity patterns, enriched signaling pathways, genomic complexity, and clinical actionability of alterations between patients with different PD-L1 expression status, to uncover the molecular underpinnings of immune heterogeneity in advanced lung adenocarcinoma and inform precision combination therapeutic strategies.