Deep learning and genome-scale modelling reveal that basal sexual dimorphism dictates Lactiplantibacillus plantarum engraftment in the murine gut.
This project investigates the ecosystem-level modulation of the murine gut microbiome induced by the intragastric administration of distinct Lactiplantibacillus plantarum strains (LM20, G7, and the commercial reference PS128) in an in vivo CD-1 murine model. The experimental cohort consists of 64 subjects equally stratified by biological sex to assess the role of sexual dimorphism in probiotic engraftment. Utilizing full-length 16S rRNA Oxford Nanopore sequencing, this dataset aims to decode non-linear ecosystem variance, identify latent functional guilds, and evaluate the mechanistic competitive niche exclusion driving the restoration of eubiosis.