Transcriptomic profiling of MET-amplified gastric cancer cells in response to capmatinib treatment
This study investigates the transcriptional response of MET-amplified gastric cancer cells to capmatinib treatment. MKN45 cells were treated with 5 nM capmatinib or vehicle control for 48 hours, followed by RNA extraction and strand-specific RNA-seq. The goal is to identify differentially expressed genes and pathways associated with capmatinib-induced autophagy and apoptosis, aiming to elucidate resistance mechanisms and potential combination therapeutic strategies for MET-amplified gastric cancer.