Garcinia cambogia Extract Alleviates Calcium Oxalate Kidney Stones and Is Associated with Gut Microbiota-Short Chain Fatty Acid Modulation in Rats
This study investigated the effects of Garcinia cambogia extract (GCE) on calcium oxalate (CaOx) kidney stone formation and its association with gut microbiota and short-chain fatty acid (SCFA) modulation in a rat model. Fifty male Sprague-Dawley rats were divided into control, CaOx model, and three GCE treatment groups (100, 300, 900 mg/kg/day). GCE treatment ameliorated renal function, reduced stone burden, and alleviated oxidative stress. 16S rRNA sequencing revealed that GCE modulated gut microbial composition and increased SCFA production, which were correlated with improved biochemical parameters. However, these findings are correlational and do not establish causality. The raw sequencing reads have been deposited in the ENA under the project accession provided here.