Alleviation of Acute Skin Ultraviolet Damage by Heyndrickxia coagulans-Fermented Gastrodia elata
This study aimed to investigate the reparative effects and underlying mechanisms of fermented Gastrodia elata on acute UVB induced skin damage in mice. An UVB damage mouse model was established, and a multi omics integrated analytical approach combining metabolomics, transcriptomics, network pharmacology, and molecular docking was employed to systematically elucidate the material basis and molecular network responsible for the reparative action. The results showed that fermentation significantly altered the metabolite profile of Gastrodia elata, and Genistein was identified as a key transdermal metabolite. Computational analysis further indicated that both the fermented product and Genistein possessed strong binding potential with the core inflammatory target Ptgs2 (COX2).