Resistant starch alleviates intestinal fibrosis by promoting acetate-mediated HDAC2-H3K27ac inhibition in fibroblasts
Dietary fibre-based interventions are of growing interest for the prevention and treatment of digestive diseases. This study investigated the effect of resistant starch (RS) on intestinal fibrosis, a stricturing condition driven by excessive extracellular matrix (ECM) accumulation. Our results demonstrated that RS alleviated intestinal fibrosis in a chronic DSS-induced colitis mouse model.Given the fermentation of RS, metagenomic sequencing revealed that RS reshapes the composition of the gut microbiota and enriches the abundance of beneficial gut bacteria.