Gut microbiota profiling in orthotopic colorectal cancer-bearing mice following AP/LCCXCR4 treatment and radiotherapy
This project investigates treatment-associated changes in the gut microbiota of orthotopic colorectal cancer-bearing mice following AP/LCCXCR4-mediated lactate depletion and radiotherapy. Fecal samples from PBS, AP + RT, and AP/LCCXCR4 + RT groups were analyzed by 16S rRNA gene sequencing to characterize microbial diversity, community composition, and differential taxa.