Gut microbiome signatures associated with cardiac remodeling in preclinical heart failure
This project investigates the gut microbiome in individuals with preclinical heart failure and its association with cardiac remodeling. Full-length 16S rRNA gene sequencing was performed on stool samples from 124 subjects with preclinical heart failure stages A and B. Subjects were followed for one year to assess adverse or reverse cardiac remodeling based on echocardiographic findings. The sequencing data were used to characterize gut microbial composition and identify microbiome signatures associated with cardiac remodeling.