Gut microbiome sequencing associated with "Size-Tailored Nanoparticle-Antibody Conjugates Overcome Hepatic Sequestration for Alzheimer's Therapy"
This project contains raw paired-end 16S rRNA gene amplicon sequencing data from nine gut microbiome samples generated in a study of size-tailored nanoparticle-antibody conjugates for Alzheimer's therapy. The bacterial and archaeal 16S rRNA V3-V4 region was amplified and sequenced on an Illumina HiSeq 2500 platform. The samples represent three experimental groups - 1F12, PEG-MSN, and PEG-MSN-1F12 - with three samples per group. The data were used to characterize gut microbial community composition and diversity, perform taxonomic and differential-abundance analyses, and predict microbial functional profiles. This project provides the raw sequencing reads and associated sample metadata supporting the gut microbiome analyses of the study.