AP1S1 drives cervical cancer progression via HOXC4/TRIM23/COX5B axis
Cervical cancer is a leading cause of cancer-related deaths in women, but the underlying molecular mechanisms remain poorly understood. In this study, we employed bulk RNA sequencing (RNA-seq) and proteomic profiling to investigate the role of AP1S1 in cervical cancer progression. We demonstrate that AP1S1 is significantly upregulated in tumor tissues and correlates with poor prognosis. Mechanistically, AP1S1 interacts with HOXC4 to suppress TRIM23-mediated ubiquitination of COX5B, thereby enhancing oxidative phosphorylation and promoting tumor cell proliferation and migration. This dataset comprises raw sequencing reads generated from SiHa cervical cancer cells to support the findings of this study.