GPR81 Pericytes Orchestrate a Vascular Gate for Reactivation of Lung Metastatic Dormancy
Disseminated tumor cells drive metastatic recurrence by maintaining long term dormancy in distant organs. Nevertheless, the metabolic microenvironmental mechanisms governing DTC reawakening remain poorly understood. Here, we identify a lung specific GPR81 pericyte subset, which establishes a vascular gate structure to orchestrate DTC reactivation and metastatic outgrowth. Using CUTTag and other approaches, we aim to characterize the features and novel mechanisms underlying epigenetic remodeling in pericytes and immune cells.