Evaluation of phlorizin intake and fecal metabolites or microbiota structure in mice
Some of the intermediates of aromatic amino acids are known to exacerbate kidney dysfunction, and some of them are derived from gut bacterial metabolism. Regulation of the bacterial metabolism would be potent strategy to prevent and/or treat the disease. In our in vitro study, phloretin, an apple chalcone, successfully suppressed bacterial production of these metabolites. Further study is needed to apply phloretin for the prevention and/or treatment of the disease. In this study, phlorizin, a glucose-conjugated form of phloretin, are dissolved in water and supplemented to mice, and then fecal metabolites or microbiota were analyzed to assess its effects of dietary intake.