Metagenomic and single-cell genomic dynamics of hospital wastewater under short-term meropenem exposure
This project investigates antimicrobial resistance (ARG) and mobile genetic element (MGE) dynamics in hospital wastewater during short-term meropenem exposure. Using combined metagenomics and single-cell genomics (SAGs), we track community- and host-level responses across a three-hour time course. The dataset provides high-resolution insights into resistance contraction, ARG-MGE co-carriage turnover, and the distribution of blaKPC-2-associated genetic structures across diverse bacterial hosts.