Fecal filterate transplantation for treatment of alcoholic liver disease
ALD involves disrupted gut-liver communication, contributing to inflammation, impaired intestinal barrier function, and metabolic disturbances that exacerbate liver injury. This study demonstrates that FFT attenuates alcohol-induced liver injury while modulating intestinal barrier-related markers, gut microbial communities, and microbial metabolites. These findings highlight the potential of cell-free microbial components as modulators of the gut-liver axis and provide a basis for developing alternative approaches to gut-based intervention in ALD.