Dysbiosis of nasal microbiota associated with hippocampal neuroimmune alterations in a mouse model of eosinophilic chronic rhinosinusitis
This project investigates alterations in the nasal and cecal microbiota and their association with neuroimmune changes in a mouse model of eosinophilic chronic rhinosinusitis (ECRS). Microbial communities in nasal mucosa and cecal contents from control and ECRS model mice were analyzed by 16S rRNA gene V3-V4 amplicon sequencing, with particular emphasis on dysbiosis of the nasal microbiota and its association with hippocampal neuroimmune alterations.