Oral microbiome diversity and community composition across multidimensional geriatric vulnerability in hospitalized older adults
Previous studies have associated frailty with alterations of the oral microbiome; however, these investigations largely compared individuals across broad age ranges or heterogeneous health conditions, making it difficult to distinguish age-related microbial changes from those associated with increasing clinical vulnerability. This study aimed to determine whether increasing multidimensional geriatric vulnerability, assessed using the Multidimensional Prognostic Index (MPI), is associated with ecological alterations of the oral microbiome within a hospitalized older population.
Previous studies have associated frailty with alterations of the oral microbiome; however, these investigations largely compared individuals across broad age ranges or heterogeneous health conditions, making it difficult to distinguish age-related microbial changes from those associated with increasing clinical vulnerability. This study aimed to determine whether increasing multidimensional geriatric vulnerability, assessed using the Multidimensional Prognostic Index (MPI), is associated with ecological alterations of the oral microbiome within a hospitalized older population.