Molecular, epigenomic, and transcriptomic analyses indicate SOX7 transcription factor as a tumor suppressor gene in multiple myeloma
Multiple myeloma (MM) represents 10% of hematological cancers, and it is currently incurable. Cancer-related genes involved in MM development are not fully known yet. Deletions in chromosome 8p23.1, harboring multiple candidate tumor suppressor genes, are observed in MM tumor samples. SOX7, a transcription factor located in 8p23.1, was reported to be silenced in many cancer types; and its ectopic expression inhibited growth of different tumor types. Herein, we investigated whether SOX7 acts as a tumor suppressor in MM or not using MM cell lines.