Fibre supplementation of EEN improves gastrointestinal function during health and disease
Studies were conducted using a human preclinical model of healthy adults and in laboratory mice. EEN with or without fibre supplementation was assessed for its effects on intestinal permeability under steady-state and acutely stressed conditions, and evaluated colonic injury in a murine model of chemically-induced colitis. Stool samples underwent 16S rRNA amplicon sequencing to assess microbial composition.