Mg-MOF-74 incorporation enhances bone regeneration
We developed a Mg-MOF-74-incorporated collagen-hydroxyapatite scaffold and evaluated its regenerative effects. Mg-PHA-COL increased Mg2+ availability, promoted tissue remodeling, and enhanced bone formation, vascularization, and mineralization. Transcriptomic analysis highlighted the cGMP-PKG signaling pathway and associated immune and regenerative responses.